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It's an order of magnitude

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IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension

Also, if youd rather take an additive-free berberine powder instead of capsules, you should know that berberine isnt exactly enjoyable to consume

It not only scavenges free radicals that can trigger excess melanin production, but it also influences the melanin-making process itself (more on that in the next section)

Bonnefont-Rousselot D, Collin F (2010) Melatonin: action as antioxidant and potential applications in human disease and aging